School of Chemistry lecturer Dr Sara Kyne returns from a 3-wk trip to Australia after giving talks at two large conferences.
Dr Sara Kyne spoke at the IUPAC Conference on Physical Organic Chemistry and 27th International Conference on Organometallic Chemistry in July.
International conferences such as these are a great way to promote your research and expertise in a field of work and we are proud to have Sara representing the School of Chemistry, University of Lincoln all the way in Australia.
The ICPOC conference was in Sydney on 8th July in the Bioorganic and Mechanisms stream: Mechanistic studies of iron(I) catalysed Ueno-Stork reactions. (See abstract below)
Other areas covered in the conference was ‘Supramolecular and Systems Chemistry’ and ‘Physical Foundations of Organic Reactivity’. The ICPOC is a biannual conference and this was its 23rd year running.
Sara’s talk at the International Conference on Organometallic Chemistry (ICOMC16) in Melbourne, Australia was on ‘Iron catalysed atom transfer radical addition reactions’ on July 19th.
Hundreds of attendees and speakers came to the events that were sponsored by large sector organisations and businesses.
Iron Catalysed Atom Transfer Radical Addition Reactions
Sara Kyne1, Cyril Ollivier2 and Louis Fensterbank2
1 School of Chemistry University of Lincoln, United Kingdom
2 Institut Parisien de Chimie Moléculaire Université Pierre et Marie Curie – Paris 6, France
Free radical carbon-carbon bond forming reactions are powerful and versatile tools for modern synthetic chemistry. Worldwide it has become increasingly important to make advances in ecological and sustainable chemistry, and for free radical chemistry in particular it is necessary to develop alternatives to traditional radical mediators, namely trialkyltin hydrides or their precursors. Transition metal complexes are particularly suitable owing to their ability to generate a variety of reactive metal species with different oxidation states. In this regard we are interested in exploring the reactivity of iron in a variety of radical reactions and subsequently developing efficient methodologies mediated by environmentally benign iron complexes.
Two novel iron catalysed atom transfer radical addition reactions have been developed (Figure 1) acting via distinct reaction pathways.[2,3] Organometallic iron(II) complexes promote Ueno-Stork reactions and the results of electrochemical experiments suggest that an anionic hydridoiron(I) species formed in situ is the catalytically active species. Iron(0) nanoparticles are readily synthesised in situ, and electron microscopy techniques have optimised catalyst design and formation, thus improving halogen atom transfer reaction efficiency.
Detailed mechanistic investigations are further expanding the scope and utility of these sustainable synthetic methodologies. Iron complexes provide ecological methods to catalyse atom-economical radical reactions, and will be important for the future progress of this chemistry.
1. 2. 3. Ekomié, A.; Lefèvre, G; Fensterbank, L.; Lacôte, E.; Malacria, M.; Ollivier, C.; Jutand, A. Angew. Chem., Int. Ed. 2012, 51, 6942-6946.
Kyne, S.H.; Derat, E.; Lefèvre, G; Blondin, G.; Fensterbank, L.; Jutand, A.; Ollivier, C. Submitted, 2016.
Kyne, S.H; Ollivier, C.; Petit, C.; Fensterbank, L. Submitted, 2016.